What does this research mean for the field?

A newly developed green UV-spectrophotometric method integrating first-derivative spectrophotometry and Fourier Self-Deconvolution enables the accurate, eco-friendly concurrent quantification of gliclazide and its alkaline degradation product without prior separation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To develop and validate sustainable, stability-indicating UV-spectrophotometric methods for the simultaneous quantification of gliclazide and its alkaline degradation product without prior physical separation.

August 24, 2026Scientific ReportsOpen Access

Sustainable stability-indicating spectra manipulations for the concurrent quantification of gliclazide and its impurity A as the possible alkaline degradation product: Multi-Color Analytical Profile Assessment

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Authors

EKEbraam B. Kamel AAAhmed Elsayed Abdelmegeed HSHanaa Saleh

Discussion

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Overview

Analytical method validation reveals precise concurrent quantification of gliclazide and its degradation product, highlighting a sustainable alternative for pharmaceutical quality control.

Key Points

To develop and validate sustainable, stability-indicating UV-spectrophotometric methods for the simultaneous quantification of gliclazide and its alkaline degradation product without prior physical separation.
Integrated first-derivative spectrophotometry (D1) and Fourier Self-Deconvolution (FSD) using ethanol as an eco-friendly solvent to resolve overlapping UV spectra.
Validated the assay according to ICH Q2(R1) guidelines under alkaline forced-degradation conditions and assessed environmental sustainability using multi-metric greenness tools (such as AGREE, GAPI, and the RGB 12 model).
Achieved linear detection ranges of 2.5–25 µg/mL for gliclazide and 2.5–15 µg/mL for its degradation product, with limits of detection spanning 0.31–0.43 µg/mL and limits of quantitation spanning 0.94–1.31 µg/mL.
Yielded mean recovery rates of 99.48 ± 0.83% for the D1 method and 100.87 ± 1.52% for the FSD method when measuring gliclazide.

Cite This Study

Kamel et al. (2026) studied this question.

synapsesocial.com/papers/6a8c0086bca056c88e6df490 https://doi.org/10.1038/s41598-026-67045-4

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August 24, 2026Scientific ReportsOpen Access

Sustainable stability-indicating spectra manipulations for the concurrent quantification of gliclazide and its impurity A as the possible alkaline degradation product: Multi-Color Analytical Profile Assessment

View Full Paper

Ask AI

Bookmark

Authors

EKEbraam B. Kamel AAAhmed Elsayed Abdelmegeed HSHanaa Saleh

Discussion

Member takes

Overview

Analytical method validation reveals precise concurrent quantification of gliclazide and its degradation product, highlighting a sustainable alternative for pharmaceutical quality control.

Key Points

To develop and validate sustainable, stability-indicating UV-spectrophotometric methods for the simultaneous quantification of gliclazide and its alkaline degradation product without prior physical separation.
Integrated first-derivative spectrophotometry (D1) and Fourier Self-Deconvolution (FSD) using ethanol as an eco-friendly solvent to resolve overlapping UV spectra.
Validated the assay according to ICH Q2(R1) guidelines under alkaline forced-degradation conditions and assessed environmental sustainability using multi-metric greenness tools (such as AGREE, GAPI, and the RGB 12 model).
Achieved linear detection ranges of 2.5–25 µg/mL for gliclazide and 2.5–15 µg/mL for its degradation product, with limits of detection spanning 0.31–0.43 µg/mL and limits of quantitation spanning 0.94–1.31 µg/mL.
Yielded mean recovery rates of 99.48 ± 0.83% for the D1 method and 100.87 ± 1.52% for the FSD method when measuring gliclazide.

Cite This Study

Kamel et al. (2026) studied this question.

synapsesocial.com/papers/6a8c0086bca056c88e6df490 https://doi.org/10.1038/s41598-026-67045-4

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