Narrative review synthesizes therapeutic applications and biology of γδ T cells in skin cancers, highlighting their emerging role as immunotherapy targets in melanoma.
γδ T cells represent an increasingly important subset of T lymphocytes in the immune response to cancer and as a platform for novel immunotherapies. The aim of this review is to synthesize recent insights into the biology and advances in therapeutic applications of γδ T cells in cutaneous malignancies, especially melanoma, within a framework of tumor immunology and recent clinical research.
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Du et al. (2026) studied this question.
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