Theoretical analysis proposes nanoparticle-induced membrane disruption triggers ancient survival genes in cancer cells, highlighting atavistic biophysical mechanisms beyond linear genetic mutations.
Current oncology remains largely constrained by the dogma of linear biochemistry, searching for solutions within nucleotide mutations while overlooking the overarching boundary architecture: the cellular membrane and the non-equilibrium thermodynamic fluxes that sustain it. If the genome represents an evolutionary library, multicellular cooperation and programmed cell death (apoptosis) are merely the modern volumes on the upper shelves. Locked deep within the genomic basement, however, lies a 4-billion-year-old archive dating back to LUCA and primordial semiconductor-doped vesicles. These ancient sequences owe no allegiance to the host organism; they code exclusively for survival within the high-stress, mechanical chaos of the Hadean Earth.
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Peter Mikuláš (2026) studied this question.
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