This review finds weak evidence for a causal relationship between most coexisting disorders or enzymopathies and malignant hyperthermia susceptibility.
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Weak evidence for most conditions should not change anesthetic risk stratification; leaves open rigorous causal studies in select disorders.
Clinical episodes and abnormal laboratory tests compatible with a diagnosis of malignant hyperthermia have been observed in patients with a diversity of syndromes, enzymopathies, and coexisting disorders thereby raising the likelihood of causal associations and heightened perioperative risk in others carrying a shared diagnosis. In the present review, we survey available published series, case reports, and the results of contracture testing in patients identified by others to be potentially predisposed to malignant hyperthermia. For most conditions, evidence for a causal relationship with malignant hyperthermia susceptibility is weak. The review concludes with suggestions for clinical management when evidence for or against an association is uncertain.
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Benca et al. (2009) studied this question.
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