Why the study?
Does combination radiation therapy and surgery improve resectability and prevent recurrence in a patient with large retroperitoneal malignant fibrous histiocytoma?
Does combination radiation therapy and surgery improve resectability and prevent recurrence in a patient with large retroperitoneal malignant fibrous histiocytoma?
Preoperative radiation therapy may reduce tumor size and enable surgical resection of initially unresectable retroperitoneal malignant fibrous histiocytoma.
May enable resection of unresectable retroperitoneal MFH; hypothesis-generating and requires prospective validation.
The case report of a patient with a large retroperitoneal malignant fibrous histiocytoma treated with a combination of radiation therapy and surgery is presented. At the time of the first laparotomy, the lesion was deemed unresectable and biopsied. Reexploration after irradiation to a dose of 3800 rad showed the tumor to be more than 50% smaller and easily resectable. There has been no recurrence during the ensuing two and a half years.
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Patel et al. (1980) studied this question.
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