Cerebral Toxoplasmosis in Multiple Myeloma

Case Studies1 May 1966Cerebral Toxoplasmosis in Multiple MyelomaATHANASIOS THEOLOGIDES, M.D., KENNETH OSTERBERG, M.D., B. J. KENNEDY, M.D., F.A.C.P.ATHANASIOS THEOLOGIDES, M.D., KENNETH OSTERBERG, M.D., B. J. KENNEDY, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1071 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of fungal and protozoal infections in patients with advanced malignant disease is increasing in frequency, in patients receiving irradiation therapy, chemotherapy or adrenal steroids. During treatment for multiple myeloma a patient developed an infection with Toxoplasma gondii that was limited to the central nervous system.CASE REPORTA 55-year-old housewife (L. K. UH 918525) was first seen in the University of Minnesota Hospitals because of fatigue of 2 years' duration and chest and back pain of 1 1/2 year's duration.The only abnormal finding on physical examination was rib tenderness. The hemoglobin was 12.2 g/100 ml, and the...References1. BOBOWSKIREED SJWG: Toxoplasmosis in an adult, presenting as a space occupying cerebral lesion. Arch. Path. (Chicago) 65: 460, 1958. MedlineGoogle Scholar2. KOEZEKLINGON THGH: Acquired toxoplasmosis: case with focal neurologic manifestations. Arch. Neurol. (Chicago) 11: 191, 1964. CrossrefMedlineGoogle Scholar3. FINCKH ES: Intercurrent infection with toxoplasma organisms found in the bone marrow of a patient with advanced reticulosarcoma. Med. J. Aust. 2: 965, 1954. CrossrefMedlineGoogle Scholar4. HEMSATHPINKERTON FAH: Disseminated cytomegalic inclusion disease and disseminated toxoplasmosis in an adult with myeloid metaplasia. Amer. J. Clin. Path. 26: 36, 1956. CrossrefMedlineGoogle Scholar5. FRENKEL JK: Pathogenesis of toxoplasmosis and of infections with organisms resembling toxoplasma. Ann. N. Y. Acad. Sci. 64: 215, 1956. CrossrefGoogle Scholar6. BACHMANNKEISERMARTENET FGAC: Die erworbene Erwachsenentoxoplasmose. Helv. Med. Acta 29: 156, 1962. Google Scholar7. CONNOLLY CS: Hodgkin's disease associated with Toxoplasma gondii. Arch. Intern. Med. (Chicago) 112: 393, 1963. CrossrefMedlineGoogle Scholar8. KEELROTHKEISERREUTTERMARTZ HJWGFG: Uber das zusammentreffen von Morbus Hodgkin und toxoplasmose. Schweiz. Med. Wschr. 93: 1465, 1963. MedlineGoogle Scholar9. CHEEVERVALSAMISRABSON AWMPAS: Necrotizing toxoplasmic encephalitis and herpetic pneumonia complicating treated Hodgkin's disease. New Eng. J. Med. 272: 26, 1965. CrossrefMedlineGoogle Scholar10. WOLFKAUFMANCOWEN AMAD: Adult toxoplasmosis. Trans. Amer. Neurol. Ass. 78: 284, 1953. Google Scholar11. BERNARDBOIRONLEVYRIPAULTDESMONTS JMJPJG: Toxoplasmose generalisée associée à une leucemic aigue. Nouv. Rev. Franc. Hemat. 2: 910, 1962. MedlineGoogle Scholar12. HOOFTDELBEKELANNOO CMJR: Leucemie et toxoplasmose. Arch. Franc. Pediat. 19: 1201, 1962. MedlineGoogle Scholar13. WERTLAKEWINTER PTTS: Fatal toxoplasma myocarditis in an adult patient with acute lymphocytic leukemia. New Eng. J. Med. 273: 438, 1965. CrossrefMedlineGoogle Scholar14. KAYHOEJACOBSBEYEMCCULLOUGH DELHKNB: Acquired toxoplasmosis. Observations on two parasitologically proved cases treated with pyrimethamine and triple sulfonamides. New Eng. J. Med. 257: 1247, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ATHANASIOS THEOLOGIDES, M.D.; KENNETH OSTERBERG, M.D.; B. J. KENNEDY, M.D., F.A.C.P.Affiliations: Minneapolis, MinnesotaFrom the Departments of Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, Minn.This study was supported in part by research grant CA-3143, National Cancer Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Athanasios Theologides, M.D., University of Minnesota Medical Center, Department of Medicine, Minneapolis, Minn. 55455. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCerebral toxoplasmosis in a patient with multiple myelomaProlonged Immunosuppression in Relapsed, Refractory Multiple Myeloma Leading to Cerebral Toxoplasmosis and Progressive Multifocal LeukoencephalopathyDiagnosis of pulmonary infection with Toxoplasma gondii in immunocompromised HIV-positive patients by real-time PCRToxoplasma-induced occlusive hypertrophic arteritis as the cause of discrete coagulative necrosis in the CNSReplyThe Prevalence and Source of Toxoplasma Infection in the EnvironmentJuxtapapillary Retinochoroiditis with a Psychiatric Disorder Possibly Caused by ToxoplasmaToxoplasmosis in the Compromised HostJOEL RUSKIN, M.D., F.A.C.P., JACK S. REMINGTON, M.D., F.A.C.P.Adult Toxoplasmosis Presenting as Polymyositis and Cerebellar AtaxiaJOHN E. GREENLEE, M.D., WARREN D. JOHNSON Jr., M.D., F.A.C.P., JUSTINIANO F. CAMPA., M.D., LESTER S. ADELMAN, M.D., MERLE A. SANDE, M.D., F.A.C.P.Immunosuppression and toxoplasmic encephalitisParaproteinämische HämoblastosenToxoplasmosisToxoplasmose adquirida, forma linfoglandular: relato de 22 casosDie ToxoplasmoseCurrent patterns of infection in multiple myelomaToxoplasmosis. Mechanisms of Infection, Laboratory Diagnosis and ManagementToxoplasmic myocarditis and pericarditisToxoplasma serology in patients with malignant diseases of the reticuloendothelial systemToxoplasmosis, Lymphoma, or Both?FLORA M. BARLOTTA, M.D., MANUEL OCHOA JR., M.D., F.A.C.P., HAROLD C. NEU, M.D., F.A.C.P., JOHN E. ULTMANN, M.D., F.A.C.P.ToxoplasmosisToxoplasmosis complicating malignancy. Experience at the national cancer instituteToxoplasma and Toxoplasmosis 1 May 1966Volume 64, Issue 5Page: 1071-1074KeywordsInfectious diseasesLower back painMultiple myelomaResearch grantsRibsSteroidsThoraxToxoplasmaToxoplasma gondiiToxoplasmosis ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...