Pluripotent stem cells (PSCs), represented primarily by embryonic stem cells and induced pluripotent stem cells (iPSCs), have a unique ability to self-renew and differentiate into all types of somatic cells. Dissecting molecular mechanisms controlling these properties is important for an efficient and safe introduction of PSCs into clinics. Growing evidence indicates that the proteostasis plays a central role in PSCs fate decisions. This review focuses on the role of the ubiquitin-proteasome system, a key member of the proteostasis network, in the regulation of pluripotency and differentiation of PSCs.
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Podenkova et al. (2023) studied this question.
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