Experimental Evidence That a DNA Polymerase Can Incorporate N7‐Platinated Guanines To Give Platinated DNA

Metal bearing nucleobase: A model DNA polymerase and N7-metalated purine triphosphate nucleotide are used to show that metalated purines can be inserted into DNA during an enzymatic in vitro synthetic process (see scheme; dNTP=deoxynucleotide triphosphate). The possibility of site-specific metalation of DNA mediated by DNA polymerase is demonstrated.