Key result
Weekly oral Methotrexate and Leflunomide led to marked improvement in 58% of cats with refractory feline rheumatoid arthritis, without serious toxicity.
Why the study?
Does weekly oral methotrexate and leflunomide improve symptoms in cats with refractory rheumatoid arthritis?
Case Report (n=12)
Does weekly oral methotrexate and leflunomide improve symptoms in cats with refractory rheumatoid arthritis?
Weekly oral methotrexate and leflunomide may provide clinical improvement in cats with refractory rheumatoid arthritis without serious toxicity.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for methotrexate-leflunomide in refractory feline RA; controlled trials needed before clinical adoption.
Feline erosive polyarthritis includes the more common periosteal proliferative polyarthritis (PPP) and the rarely seen rheumatoid arthritis (RA) (11). During the past three years, 12 patients with definite feline rheumatoid arthritis, which did not respond well to conventional therapy, were treated with 7.5 mg of Methotrexate and 70 mg Leflunomide, given weekly by the oral route. The average age of the cats was 5.9 years (range 2.5 to 10 years). Siamese cats were over represented. Seven of the 12 (58%) cats showed a marked improvement, usually within four weeks. Once maximum improvement was obtained the dosage was decreased. Serious toxicity was not noted and carcinogenetic effect was not seen during the course of this study.
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Fikry Younan Hanna (2005) conducted a case report in feline rheumatoid arthritis (n=12). Methotrexate and Leflunomide was evaluated on marked improvement. Weekly oral Methotrexate and Leflunomide led to marked improvement in 58% of cats with refractory feline rheumatoid arthritis, without serious toxicity.
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