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Summary. Five examples of human anti‐Lea were subjected to DEAE‐cellulose chromatography. In each case antibody activity was demonstrable in the IgG fractions by the binding of 125I‐Lea glycoprotein. The Lea specificity of these reactions was established by absorption experiments with red cells and with serum from donors of known Lewis phenotypes. Antibody activity was also detected in IgG concentrates of two anti‐Lea antisera by gel diffusion against Lea glycoprotein. Inhibition curves obtained in a radioimmunoassay system suggest that IgC anti‐Lea has a significantly lower binding constant than IgM anti‐Lea. Failure to detect anti‐Lea by serological techniques with red cells may be related to the low binding constant.
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A. M. Holburn (1974) studied this question.
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