Thorotrast-induced hepatoma

A case of thorotrast-induced hepatoma is presented. The patient was given Thorotrast intravenously, in 1943, for diagnostic x-ray studies. Autoradio-graphic and electron microscopic studies confirm the diagnosis 28 years later. A review of the world's literature is tabulated. A short history of the use of thorotrast is given, and its carcinogenic potential is discussed. The question of chemical vs. radiation carcinogenesis remains unsettled. A plea is made for earlier diagnosis, so that an effective plan of treatment may be attempted.