Summary Incorporation of C14-amino acid into serum proteins by cell lines and strains in vitro was studied using the technique of autoradiography of immunoelectrophoretic patterns. Fibroblast-like cells of both human and murine origin produced serum proteins associated with complement activity. Epithelial-like cells of several established cell lines produced β1C. Lymphoblastic cells of murine origin synthesized transferrin. A rat hepatoma cell line produced strong labeling of albumin, β1C and transferrin. The dissociation between production of β1C and transferrin in murine cell lines is discussed in relation to the production of both these proteins by mouse lymphoid tissue and peritoneal macrophages. A few fresh tumor tissues were also studied. Of them, an epithelioma of the thymus was particularly interesting, since it actively produced both β1C and β1E.
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Stecher et al. (1967) studied this question.