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Unfractionated suppressor tRNAtyrSuSuiii+ can insert tyrosine at the nonsense site of an amber mutant of f2 bacteriophage but fails to synthesize polytyrosine in response to poly[r(U-A-G)]. Purified tRNAtyrSuSuiii+ can, however, propagate across a repeated U-A-G termination sequence and form polytyrosine as directed by poly[r(U-A-G)]. The recognition of tandem amber nonsense sequence only by the purified suppressor tRNA may be due to the increased concentration of tRNAtyrSuSuiii+.
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Ghosh et al. (1972) studied this question.
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