A concise synthesis of (S)-macrostomine has been accomplished in five steps from natural nicotine in 19% overall yield via a pyridyne Diels-Alder cycloaddition reaction as the key step. A Kumada cross-coupling reaction on a 1-chloroisoquinoline intermediate provided the natural product.
No takes yet. Share an insight, caveat, or question.
Enamorado et al. (2010) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: