Key result
Among high bleeding risk patients treated with 1-month DAPT, the 2-year rate of cardiac death or MI was similar between those with and without bifurcation PCI (12.2% vs 11.6%; P=.92).
Why the study?
Does 1-month DAPT after PCI with Resolute Onyx ZES result in similar 2-year ischemic outcomes for high bleeding risk patients with bifurcation lesions compared to those without?
Does 1-month DAPT after PCI with Resolute Onyx ZES result in similar 2-year ischemic outcomes for high bleeding risk patients with bifurcation lesions compared to those without?
A 1-month DAPT regimen appears feasible and safe in high bleeding risk patients undergoing contemporary zotarolimus-eluting stent-based bifurcation PCI, particularly with a provisional 1-stent strategy.
Percutaneous coronary intervention (PCI) of bifurcation lesions accounts for approximately 15% to 20% of all procedures and is associated with an increased early and late risk of ischemic and bleeding complications. Although there is general agreement, supported by the European Bifurcation Club, that a stepwise provisional approach is recommended for most coronary bifurcations, including the left main, the optimal antithrombotic regimen and duration remain undefined.1
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G. Stankovic (2026) conducted an editorial in High bleeding risk requiring percutaneous coronary intervention (n=1,507). Bifurcation PCI vs. Non-bifurcation PCI was evaluated on Composite of cardiac death or myocardial infarction at 2 years (p=.92). Among high bleeding risk patients treated with 1-month DAPT, the 2-year rate of cardiac death or MI was similar between those with and without bifurcation PCI (12.2% vs 11.6%; P=.92).
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