A novel synthesis methodology for the construction of functionalized dihydropyrones has been developed with amines, glyoxylic acid, and 4-substituted-1,2-oxaborol-2(5 H )-ols from the Petasis reaction. Mechanistic investigation indicated the intermolecular S N 2 cyclization to provide 3,6-dihydro-2 H -pyran-2-ones (3,6-DHP) and 5,6-dihydro-2 H -pyran-2-ones (5,6-DHP) in one step with moderate to excellent yields.
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Li et al. (2019) studied this question.
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