Highly Efficient Acetalization and Ketalization Catalyzed by Cobaloxime under Solvent-Free Condition

An efficient catalytic system was developed for the acetalization and ketalization of carbonyl compounds with polyhydric alcohols under mild solvent-free conditions. In the presence of 0.1 mol% CoCl2 and 0.2 mol% dimethylglyoxime at 70 °C under 5 KPa pressure for 1 h, 95.3% conversion of cyclohexanone and 100% selectivity of the corresponding cyclic ketal could be obtained, where TOF reached as high as 953 h−1. It is proposed that the in situ generated planartetracoordinate cobaloxime played the key role in the catalytic cycle and was responsible for the excellent catalytic performance.