Key result
Adolescents with neurocardiogenic syncope had significantly higher P-wave dispersion on 12-lead electrocardiography compared to healthy controls (69.7 vs. 45.5 msec, P<0.001).
Why the study?
Is P-wave dispersion increased in adolescents with neurocardiogenic syncope compared to healthy controls?
Case-Control (n=109)
Yes
Is P-wave dispersion increased in adolescents with neurocardiogenic syncope compared to healthy controls?
P-wave dispersion is significantly prolonged in adolescents with neurocardiogenic syncope and may serve as a useful electrocardiographic parameter of cardiac autonomic dysfunction.
May indicate autonomic dysfunction in adolescent syncope; hypothesis-generating and requires prospective validation before clinical use.
Purpose: Neurocardiogenic syncope (NCS) is the most frequent cause of fainting during adolescence. Inappropriate cardiovascular autonomic control may be responsible for this clinical event. The headup tilt test has been considered a diagnostic standard, but it is cumbersome and has a high falsepositive rate. We performed a study to evaluate whether P-wave dispersion (PWD) could be a useful electrocardiographic parameter of cardiac autonomic dysfunction in children with NCS. Methods: Fifty-four patients with NCS (28 boys and 26 girls; mean age, 12.31.4 years) and 55 ageand sex-matched healthy controls were enrolled. PWD was obtained as the difference between maximum and minimum durations of the P wave on standard 12-lead electrocardiography in all patients and controls Results: The value of PWD was significantly higher in the syncope group than in the control group (69.719.6 msec vs. 45.517.1 msec, respectively; P<0.001). The minimum duration of P wave was shorter in the syncope group than in the control group (43.816.8 msec vs. 53.510.7 msec, respectively; P<0.001). Left atrial volume was not different between the groups on transthoracic echocardiography. Conclusion: PWD on echocardiography could be used as a clinical parameter in patients with NCS.
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Lee et al. (2016) conducted a case-control in Neurocardiogenic syncope (n=109). Neurocardiogenic syncope vs. Healthy controls was evaluated on P-wave dispersion (PWD) (p=<0.001). Adolescents with neurocardiogenic syncope had significantly higher P-wave dispersion on 12-lead electrocardiography compared to healthy controls (69.7 vs. 45.5 msec, P<0.001).
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