All articles of this category A complementary diastereofacial selectivity is achieved in the addition of 2-lithiothiazole 1b to precomplexed C -galactopyranosyl nitrone 5 with MgBr 2 - or ZnCl 2 and Et 2 AlCl or TiCl 4 , giving rise after the thiazole-to-aldehyde unmasking, to the epimeric amino-dialdoses 9 and 15 , advanced intermediates in syntheses of destomic acid and lincosamine respectively. A similar result is obtained by using 2-thiazolylmagnesium bromide 1c and 2-diethylaluminum)thiazole 1d in the presence of the above Lewis acids.
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Dondoni et al. (1993) studied this question.