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A highly active catalyst system based upon a biaryl monophosphine ligand, XPhos, for the palladium‐catalyzed Stille reaction has been developed. This method allows for the coupling of aryl chlorides with a range of tributylarylstannanes to produce the corresponding biaryl compounds in good to excellent yields (61–98%) in short reaction times (4 h). Palladium(II) acetate [Pd(OAc)2] and XPhos in a 1:1.1 ratio were milled into a fine powder that was used as pre‐catalyst for these reactions.
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Naber et al. (2008) studied this question.
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