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September 1, 2006Human Molecular Genetics

Dipsogenic genes associated with weight changes during Ironman Triathlons

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Why the study?

Are polymorphisms in the ACE, BDKRB2, NOS3 and/or 5-HTT genes associated with weight changes during an Ironman Triathlon in Caucasian male triathletes?

Population

428 Caucasian male triathletes participating in the 2000 and 2001 226 km South African Ironman Triathlons

Design

Cohort

Follow-up

Duration of the 226 km triathlon

Authors

CSColleen SaundersUniversity of Cape TownLMLiesl de MilanderTHTamara Hew‐ButlerWayne State University

Discussion

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Implication

Genotypes linked to greater weight loss in triathletes; hypothesis-generating for serotonergic and bradykinin pathways in thirst regulation, should not yet change practice.

Structured PICO

Are polymorphisms in the ACE, BDKRB2, NOS3 and/or 5-HTT genes associated with weight changes during an Ironman Triathlon in Caucasian male triathletes?

P
Population
428 Caucasian male triathletes participating in the 2000 and 2001 226 km South African Ironman Triathlons
I
Intervention
Polymorphisms within the ACE, BDKRB2, NOS3 and/or 5-HTT genes
O
Outcome
Relative weight loss during the triathlon (categorized as 0-3%, 3-5% and >5%)surrogate

Specific functional genotypes in the 5-HTT and BDKBR2 genes are associated with larger weight losses during ultra-endurance exercise, suggesting involvement of serotonergic and bradykinin pathways in thirst regulation.

Cite This Study

Saunders et al. (2006) studied this question.

synapsesocial.com/papers/6a8c1aeff8241cb45bfb8238https://doi.org/10.1093/hmg/ddl240
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin-Angiotensin Role in Thirst: Paradoxical Enhancement of Drinking by Angiotensin Converting Enzyme Inhibitor1973 · 84 citations
  2. 2The ACE Gene and Endurance Performance during the South African Ironman Triathlons2004 · 129 citations
  3. 3Problem1992 · 379 citations