Key result
The apolipoprotein E epsilon4 allele may confer a beneficial effect on cognitive measures early in life, followed by greater recruitment of brain regions to compensate for preclinical Alzheimer's disease declines in older age.
Proposes a revised compensatory mechanism recruitment hypothesis for the apolipoprotein E epsilon4 allele across the lifespan in relation to Alzheimer's disease.
Suggests age-dependent APOE ε4 effects; extends compensatory hypothesis but leaves open prospective validation before any clinical consideration.
The association between the apolipoprotein E epsilon4 allele and Alzheimer's disease (AD) is well-established. Functional neuroimaging research has supported a compensatory mechanism recruitment hypothesis whereby nondemented epsilon4 participants use additional cognitive resources to buffer against episodic memory declines in older age, a mechanism that is presumably associated with encroaching disease. However, recent studies have implicated a beneficial effect associated with the epsilon4 allele early in the life span. These studies suggest a revised hypothesis whereby epsilon4 persons perform better on cognitive measures early in the life span and then show greater recruitment of brain regions during performance to compensate for declines in older age caused by preclinical AD.
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Han et al. (2008) conducted a review in Alzheimer's disease. Apolipoprotein E epsilon4 allele was evaluated. The apolipoprotein E epsilon4 allele may confer a beneficial effect on cognitive measures early in life, followed by greater recruitment of brain regions to compensate for preclinical Alzheimer's disease declines in older age.
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