Key result
Catheter ablation of WPW in LVH triggers persistent anterior ST elevation via electrotonic modulation.
Case Report (n=1)
WPW patients may develop anterior ST-segment elevation post-ablation due to electrotonic modulation, and concurrent LVH may prolong the time for ST segments to normalize.
Post-ablation ECG changes may resolve without intervention; this case leaves open their frequency and significance in WPW with LVH.
A 47-year-old male with Wolff-Parkinson-White syndrome (WPW) and left ventricular hypertrophy (LVH) was admitted for transient loss of consciousness. Intracardiac electrophysiological examination identified a left posterior septal accessory pathway, which was successfully ablated via radiofrequency catheter ablation. Postoperative electrocardiogram (ECG) showed J-ST segment elevation in anterior leads V2-V4. At 2-week follow-up, the J point and ST segment elevation in leads V2-V4 had diminished but not fully resolved. Due to the electrotonic modulation mechanism, WPW patients may develop anterior ST-segment elevation post-ablation, and LVH may prolong the time for the ST segments to normalize.
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Zhou et al. (2025) conducted a case report in Wolff-Parkinson-White syndrome (WPW) and left ventricular hypertrophy (LVH) (n=1). Radiofrequency catheter ablation was evaluated on J-ST segment elevation in anterior leads V2-V4. Radiofrequency catheter ablation in a patient with WPW and LVH resulted in anterior ST-segment elevation that had not fully resolved at 2 weeks due to electrotonic modulation.
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