What question did this study set out to answer?

To determine whether laryngeal closure following hypoxic gasps improves autoresuscitation capability in mouse strains with differing survival profiles.

January 23, 2009Journal of Applied PhysiologyOpen Access

Laryngeal constriction during hypoxic gasping and its role in improving autoresuscitation in two mouse strains

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To determine whether laryngeal closure following hypoxic gasps improves autoresuscitation capability in mouse strains with differing survival profiles.
Tested autoresuscitation capacity across repeated hypoxia trials in autoresuscitation-competent C57/BLJ mice and autoresuscitation-deficient SWR/J mice.
Evaluated the physiological impact of elevated end-inspiratory lung volume immediately after gasping by comparing upper airway-intact mice with tracheostomized mice.
Both mouse strains maintained elevated lung volume post-gasp, but this breath-holding response enhanced autoresuscitation capability only in C57/BLJ mice.
SWR/J mice exhibited shorter breath-hold durations than C57/BLJ mice, demonstrating a central nervous system deficiency in regulating glottic closure during hypoxia.

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Implication

Experimental study reveals gasp-associated breath holding aids autoresuscitation in resilient mice, highlighting central nervous defects in vulnerable strains.

Cite This Study

Song et al. (2009) studied this question.

synapsesocial.com/papers/6a8c1dffe6afc07dcbf46579 https://doi.org/10.1152/japplphysiol.91192.2008

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Implication

Experimental study reveals gasp-associated breath holding aids autoresuscitation in resilient mice, highlighting central nervous defects in vulnerable strains.

Laryngeal constriction during hypoxic gasping and its role in improving autoresuscitation in two mouse strains

Key Points

Discussion

Implication

Cite This Study

Laryngeal constriction during hypoxic gasping and its role in improving autoresuscitation in two mouse strains

Key Points

Discussion

Implication

Cite This Study

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