Key result
A 33-year-old male with normal baseline renal function developed warfarin-related acute kidney injury, presenting with a rise in serum creatinine to 2.6 mg/dl and hematuria on day 22 of therapy.
Case Report (n=1)
No
Warfarin can cause acute kidney injury (warfarin-related nephropathy) even in patients with normal baseline renal function during episodes of over-anticoagulation.
Clinicians should consider warfarin-related nephropathy in AKI on warfarin; case report leaves open incidence and risk factors in normal renal function.
Warfarin is an oral anticoagulant used extensively in clinical practice; However, its side-effect of causing renal damage has been recently detected. The mechanism leading to renal damage is glomerular hemorrhage and red blood cell tubular casts prothrombin time. Recently, it was found that warfarin causes renal damage in patients with chronic kidney disease and is also associated with progression of renal disease. Warfarin causing acute kidney injury in patients with normal renal function is a rare manifestation. It is important to be aware of this condition as its innocuous presence can lead to chronic kidney disease if not corrected in time. Further studies have also found that novel oral anticoagulants such as dabigatran also cause a similar syndrome and hence a new term called anticoagulant-related nephropathy is now in vogue.
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Mendonca et al. (2017) conducted a case report in Warfarin-related acute kidney injury (n=1). Warfarin was evaluated on Development of acute kidney injury. A 33-year-old male with normal baseline renal function developed warfarin-related acute kidney injury, presenting with a rise in serum creatinine to 2.6 mg/dl and hematuria on day 22 of therapy.
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