UV-assisted synthesis of hydroxyapatite from eggshells at ambient temperature: cytotoxicity, drug delivery and bioactivity

the bioactivity, cytotoxicity and the drug (ciprofloxacin) loading-releasing response, which was encouraging. The results of the cell viability assays complied an insignificant cytotoxicity and the simulated body fluid immersion test indicated the bioactivity was within the acceptable range. On the other hand, to better understanding the drug ejection and associated transport phenomenon, two kinetic models (Higuchi and Ritger-Peppas models) were used and a diffusion controlled ciprofloxacin release mechanism was observed using the Higuchi model. However, the experimental outcomes of a drug delivery response exposed UV-Hap as a favorable vehicle for drug loading and release. Hence, this research highlights the prospects of a UV-assisted synthesis method as a green route for the synthesis of Hap to be applied in biomedical fields.