Key result
Bilayer polymeric nanoparticles featured low burst effect and allowed for sequential release of PDGF following co-release of VEGF and bFGF, which promoted angiogenesis.
Bilayer polymeric nanoparticles offer a promising delivery system for the spatiotemporal control of growth factor release in cardiovascular regenerative medicine.
Hypothesis-generating for spatiotemporal growth factor delivery in cardiac repair; clinical translation unproven.
AIM: Cardiac tissue engineering aims to develop engineered constructs for myocardial infarction repair, where a challenge is the control of growth factor (GF) sequential release. Herein, bilayer polymeric nanoparticles composed of a GF-encapsulating core surrounded by rate-regulating shell were developed for sequential GF release. MATERIALS & METHODS: Single and bilayer polymeric nanoparticles were fabricated, characterized and biologically assessed. A novel 'Geno-Neural model' was developed and validated for rate-programming of the nanoparticles. RESULTS: The bilayer nanoparticles featured low burst effect and time-delayed release, and allowed for sequential release of PDGF following co-release of VEGFand bFGF, which promoted angiogenesis. CONCLUSION: The nanoparticulate delivery system, along with the Geno-Neural model, offers great potential for spatiotemporal control of GF release for cardiovascular regenerative medicine.
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Izadifar et al. (2016) studied Myocardial infarction repair. Bilayer polymeric nanoparticles for sequential growth factor release vs. Single polymeric nanoparticles was evaluated on Sequential release of growth factors and promotion of angiogenesis. Bilayer polymeric nanoparticles featured low burst effect and allowed for sequential release of PDGF following co-release of VEGF and bFGF, which promoted angiogenesis.
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