Key result
Intraoperative visceral flow normalization linked to ~51-point lower mortality in acute type A aortic dissection.
Why the study?
Visceral malperfusion is a major determinant of early mortality in acute type A aortic dissection, making rapid identification and classification of malperfusion mechanisms crucial to guide treatment decisions.
Does intraoperative transpericardial ultrasound-guided assessment of visceral perfusion stratify risk and guide surgical management in patients with acute type A aortic dissection?
Observational (n=108)
No
Does intraoperative transpericardial ultrasound-guided assessment of visceral perfusion stratify risk and guide surgical management in patients with acute type A aortic dissection?
Absolute Event Rate: 9.1% vs 60%
p-value: p=<0.001
Intraoperative transpericardial ultrasound successfully differentiates dynamic from static visceral malperfusion in real time during acute type A aortic dissection repair, effectively guiding the selective use of complex adjunctive surgical and endovascular interventions.
Visceral flow normalization was associated with lower mortality; leaves open whether ultrasound-guided strategies improve outcomes in prospective trials.
Objectives: Visceral malperfusion remains a major determinant of early mortality in acute type A aortic dissection. Rapid identification and classification of malperfusion mechanisms are crucial to guide treatment decisions and improve outcomes. Methods: We retrospectively analyzed 108 patients undergoing surgical repair for acute type A aortic dissection. Transpericardial ultrasound was performed intraoperatively in 75 patients at 1 or more timepoints (pre-, intra-, or postcardiopulmonary bypass). Visceral flow in the superior mesenteric artery and celiac trunk was graded semiquantitatively. Flow improvement after cardiopulmonary bypass was considered diagnostic of dynamic malperfusion. Postoperative outcomes and causes of death were analyzed in relation to perfusion trends. Results: Visceral malperfusion was diagnosed in 26 patients (24.1%). Superior mesenteric artery flow normalized intraoperatively in 22 (84.6%), indicating dynamic obstruction. Patients with flow normalization had significantly lower mortality (9.1%) than those with persistent malperfusion (60%). Transpericardial ultrasound findings guided surgical decision making, supporting extended arch repair or endovascular adjuncts only when flow remained impaired. Thirty-day mortality was 22.2% overall, with multiorgan failure and ischemia accounting for most deaths in patients with malperfusion. Conclusions: Transpericardial ultrasound is a valuable tool for intraoperative assessment of visceral perfusion. It enables real-time distinction between reversible and irreversible malperfusion, supports a perfusion-guided repair-first strategy, and may reduce unnecessary interventions while improving risk stratification and outcomes.
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Lorenz et al. (2026) conducted an observational in Acute type A aortic dissection (n=108). Intraoperative flow normalization (reversible malperfusion) vs. Persistent malperfusion was evaluated on Mortality (p=<0.001). Patients with acute type A aortic dissection who achieved intraoperative visceral flow normalization had significantly lower mortality than those with persistent malperfusion (9.1% vs 60%).
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