Key result
Frailty in older adults undergoing radical surgery for gastrointestinal tumors increased the odds of severe postoperative complications (OR 1.492, p=0.02) and worsened recovery.
Why the study?
The relationship between frailty and complication severity, as well as risk factors for complications following radical surgery in older people with gastrointestinal malignancies, was unclear.
Does frailty increase the risk and severity of postoperative complications in older people undergoing radical surgery for a gastrointestinal tumour?
Observational
Does frailty increase the risk and severity of postoperative complications in older people undergoing radical surgery for a gastrointestinal tumour?
Odds Ratio: 1.492
p-value: p=0.02
Frailty is a significant independent predictor of severe postoperative complications, worse recovery, and higher costs in older patients undergoing radical gastrointestinal tumour surgery.
This is the authors' abstract. We don't add key points for this paper.
OBJECTIVE: Frailty is associated with postoperative complications in older people with gastrointestinal malignancies. However, the relationship between frailty and complication severity, as well as the risk factors for complications after radical surgery, is still unclear. METHODS: Frailty was assessed using a modified Frailty Index (mFI) score, and the correlation between frailty and postoperative complications was compared between frail and non-frail groups. Complication severity was evaluated using the Clavien-Dindo (C-D) system, and independent risk factors for postoperative complications were identified through odds ratios (OR) using multivariate logistic analysis. The participants were divided into non-frailty and frailty groups based on the mFI. RESULTS: The frailty group had fewer patients aged 60-69 years (19% vs. 31%, p = .03) and a higher incidence of moderate CCI (52% vs. 69%, p = .001). Frailty was strongly linked to postoperative complications, including pulmonary infections (16% vs. 8%, p = .009), pulmonary embolism (8% vs. 3%, p = .02) and acute kidney injury (14% vs. 6%, p = .005). Older frail patients experienced more severe complications, with higher rates of C-D grade III (23% vs. 10%, p = .004) and grade V (6% vs. 1%, p = .004). Multivariate analysis found that frailty (OR: 1.492, p = .02), age greater than 70 years (OR: 1.239, p = .04) and severe comorbidities increased the OR of severe complications. Additionally, frail patients had poorer recovery, with higher in-hospital mortality (4% vs. 0%, p = .01), more ICU readmissions (11% vs. 3%, p = .005), longer stays (9 vs. 8 days, p < .001) and higher costs (48,035 RMB vs. 43,792 RMB, p < .001). CONCLUSIONS: Older frail adults experienced more severe complications and had worse postoperative recovery.
Supports preoperative frailty screening in older GI cancer patients; leaves open whether interventions reduce complications.
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Peng et al. (2025) conducted an observational in Gastrointestinal malignancies. Frailty (modified Frailty Index) vs. Non-frailty was evaluated on Severe postoperative complications (OR 1.492, p=0.02). Frailty in older adults undergoing radical surgery for gastrointestinal tumors increased the odds of severe postoperative complications (OR 1.492, p=0.02) and worsened recovery.
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