Key result
Open cholecystectomy was independently associated with higher all-cause inpatient mortality compared with laparoscopic cholecystectomy (adjusted OR 6.4; 95% CI 5.5-7.4; p<0.001).
Why the study?
The study was conducted to compare inpatient outcomes between open and laparoscopic cholecystectomy.
Does open cholecystectomy compared with laparoscopic cholecystectomy increase the risk of myocardial infarction and all-cause mortality in patients undergoing cholecystectomy?
Observational (n=409,528)
Yes
Does open cholecystectomy compared with laparoscopic cholecystectomy increase the risk of myocardial infarction and all-cause mortality in patients undergoing cholecystectomy?
Open cholecystectomy is associated with a significantly higher risk of perioperative myocardial infarction and inpatient mortality compared to laparoscopic cholecystectomy.
Answers are grounded in this paper and cite their sources.
May support laparoscopic preference to reduce perioperative MI and mortality risk; observational data leaves causality open for randomized confirmation.
Aim: We compared inpatient outcome data of open (OC) versus laparoscopic cholecystectomy (LC). Patients & methods: We used the National Inpatient Samples database from 2010–2014. Results: LC was done in 340,999 and OC in 68,529 OC patients. In 2010, ST-elevation myocardial infarction (STEMI) prevalence was 0.2 versus 0% (OR: 3.1, CI: 1.7–5.5; p < 0.001), non-STEMI 1 versus 0.4% (OR: 2.5 CI: 2.0–3.0; p < 0001), mortality 3.4 versus 0.4% (OR: 9.2, CI: 7.9–10.6; p < 0001). After multivariate adjustment, OC remained independently associated with STEMI, non-STEMI and all-cause inpatient mortality (mortality multivariate OR: 6.4, CI: 5.5–7.4; p < 0001, STEMI OR: 2.2. CI: 1.2–3.9; p = 0.007, non-STEMI OR: 1.5, CI: 1.3–1.9; p < 0001). Conclusion: OC is independently associated with STEMI, non-STEMI and all-cause inpatient mortality compared with LC.
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Keele et al. (2023) conducted an observational in Cholecystectomy (n=409,528). Open cholecystectomy vs. Laparoscopic cholecystectomy was evaluated on All-cause inpatient mortality (OR 6.4, 95% CI 5.5-7.4, p=<0.001). Open cholecystectomy was independently associated with higher all-cause inpatient mortality compared with laparoscopic cholecystectomy (adjusted OR 6.4; 95% CI 5.5-7.4; p<0.001).
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