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Red cells incubated with N‐acetylcysteine or D‐penicillamine in appropriate concentrations become sensitive to lysis by acidified normal human serum, i.e. become PNH‐like cells and give a positive Ham test. At the same time the cells lose some of their acetylcholinesterase activity. Substances active in this way share a common chemical grouping:
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Sandre et al. (1968) studied this question.
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