Key result
New onset atrial fibrillation in critically ill septic patients is associated with high mortality rates and poor outcomes, serving as an indicator of the severity of critical illness.
Cardiac arrhythmias, particularly new-onset atrial fibrillation, are common in critically ill septic patients and serve as an indicator of illness severity and poor prognosis.
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New-onset AF signals high-risk sepsis; confirms prognostic value but leaves open whether rhythm control improves outcomes.
Progressive cardiovascular deterioration plays a central role in the pathogenesis of multiple organ failure (MOF) caused by sepsis. Evidence of various cardiac arrhythmias in septic patients has been reported in many published studies. In the critically ill septic patients, compared to non-septic patients, new onset atrial fibrillation episodes are associated with high mortality rates and poor outcomes, amongst others being new episodes of stroke, heart failure and long vasopressor usage. The potential mechanisms of the development of new cardiac arrhythmias in sepsis are complex and poorly understood. Cardiac arrhythmias in critically ill septic patients are most likely to be an indicator of the severity of pre-existing critical illness.
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Schwartz et al. (2015) conducted a review in Sepsis and septic shock. Sepsis vs. Non-septic patients was evaluated. New onset atrial fibrillation in critically ill septic patients is associated with high mortality rates and poor outcomes, serving as an indicator of the severity of critical illness.
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