Why the study?
How do different antihypertensive agents affect serum lipids and lipoproteins?
How do different antihypertensive agents affect serum lipids and lipoproteins?
When selecting antihypertensive therapy, clinicians should consider the drug's effect on lipid profiles to avoid negating the cardiovascular benefits of blood pressure reduction.
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Consider lipid effects in antihypertensive selection; leaves open net cardiovascular impact.
• Hypertension is a major risk factor for arteriosclerotic vascular disease. Despite intensive antihypertensive Intervention, the risk of cardiovascular disease has not declined appreciably. Many of the antihypertensive agents have been shown to elevate total serum cholesterol and triglyceride levels or lower the high-density lipoprotein-cholesterol level. Thus, the antihypertensive agents chosen may negate the beneficial effects of a lower blood pressure. Our purpose is to review all available antihypertensive medications and their influence on lipoprotein metabolism. Choosing the antihypertensive therapy least likely to worsen or precipitate other known cardiovascular risk factors is important. Cost and side effect profiles must also be considered in choosing the best antihypertensive regimen for your patients. (Arch Intern Med1988;148:1280-1288)
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Claude K. Lardinois (1988) studied this question.
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