Lipoxygenase was extracted from mouse epidermal cells and partially purified by ammonium sulfate precipitation. Using a biological oxygen monitor for activity measurements and linoleic acid as substrate, the effect of a series of flavonoids on lipoxygenase activity was determined. Flavone itself did not inhibit lipoxygenase, but hydroxylated derivatives retaining the double bond in the 2,3 position and having a hydroxyl group in the 3 position (such as quercetin and 3-hydroxy-flavone) were potent lipoxygenase inhibitors compared to flavonoids without those particular functional groups.
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Wheeler et al. (1986) studied this question.