Three potent anticancer drugs, mitomycin C (MMC), adriamycin (ADR) and carboquone (CQ), were microencapsulated with ethylcellulose in the principles of coacervation with certain modifications and the microcapsules thus prepared were examined with the scanning electron microscope. It was demonstrated in vitro and in vivo experiments that the release of action of microencapsulated MMC was made sustained and long lasting. The in vitro release of ADR and CQ from the microcapsules was also examined.
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Unno et al. (1981) studied this question.