Key result
Del Nido cardioplegia was associated with a lower need for immediate postoperative IABP (5.9% vs 9.1%, p=0.021) and similar 30-day mortality (2.9% vs 3.3%, p=1.00) compared to St. Thomas cardioplegia.
Why the study?
Del Nido cardioplegia has gained favor, but its use in the Asian population may be associated with certain challenges.
Does Del Nido cardioplegia improve clinical outcomes compared to St. Thomas cardioplegia in adults undergoing open heart surgery?
Cohort (n=614)
No
Does Del Nido cardioplegia improve clinical outcomes compared to St. Thomas cardioplegia in adults undergoing open heart surgery?
Del Nido cardioplegia provides comparable 30-day mortality and MACE to St. Thomas cardioplegia in adults undergoing open heart surgery, with a potentially lower need for immediate postoperative IABP.
Comparable 30-day mortality and MACE with DNC versus STC; leaves open whether RCTs will show outcome differences in adults.
Background: Del Nido cardioplegia (DNC) is a single-dose, high potassium, low-volume cardioplegia solution that has grown in favor recently. However, the use of DNC in the Asian population may be associated with certain challenges. Methods: Between January 2017 and April 2022, DNC was used for myocardial protection in this single-center retrospective study. In total, 5731 patients underwent open heart surgeries, where 310 patients received DNC for single or multiple procedures. A total of 307 pair of propensity-matched patients from DNC and cold blood St. Thomas cardioplegia (STC) were compared. Results: In total, 5085 patients with STC and 310 patients with DNC from the cohort were matched, reflecting the initial group sizes before propensity matching. About 307 patient pairs were included in the final analysis after propensity matching with the interest variables. In the STC group, the requirement for an immediate postoperative intra-aortic balloon pump (IABP) was significantly higher [18 (5.9%) in DNC versus 28 (9.1%) in STC, p = 0.021]. A 30-day mortality was comparable between the DNC and STC groups (2.9% versus 3.3%, p = 1.00). Major adverse cardiac events (MACE) (2.6% versus 3.6%, p = 0.648) showed no difference between the groups. In both single and multiple procedure subgroups, there were no statistically significant differences in 30-day mortality and MACE incidences when comparing STC and DNC. Conclusion: The use of DNC in adults is acceptable and adaptable. Comparable clinical outcomes between STC patients and DNC were revealed by our investigation. There were no appreciable differences in 30-day mortality or MACE despite the STC group having a much higher need for immediate postoperative IABP.
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Sazzad et al. (2023) conducted a cohort in Open heart surgeries (n=614). Del Nido cardioplegia vs. Cold blood St. Thomas cardioplegia was evaluated on 30-day mortality (p=1.00). Del Nido cardioplegia was associated with a lower need for immediate postoperative IABP (5.9% vs 9.1%, p=0.021) and similar 30-day mortality (2.9% vs 3.3%, p=1.00) compared to St. Thomas cardioplegia.
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