Key result
Del Nido cardioplegia was as safe as cold blood cardioplegia regarding renal NIRS, creatinine, and eGFR changes during congenital heart surgery, despite a higher increase in urea at 48 hours (p=0.028).
Why the study?
The study aimed to evaluate the effects of del Nido versus cold blood cardioplegia on renal functions in children undergoing cardiac surgery for congenital heart disease.
Does del Nido cardioplegia improve or preserve renal function outcomes compared to cold blood cardioplegia in pediatric patients undergoing congenital heart surgery?
RCT (n=119)
Computer-generated allocation software
No
Does del Nido cardioplegia improve or preserve renal function outcomes compared to cold blood cardioplegia in pediatric patients undergoing congenital heart surgery?
Del Nido cardioplegia is as safe as cold blood cardioplegia regarding renal function outcomes in pediatric congenital heart surgery, despite being associated with longer cardiopulmonary bypass times.
Supports equivalent renal safety of del Nido versus cold blood cardioplegia in pediatric congenital heart surgery; extends RCT evidence on key markers.
We aimed to evaluate the effect of del Nido (DN) and cold blood (CB) cardioplegia on renal functions in children undergoing cardiac surgery for congenital heart disease (CHD). Methods: This study was conducted prospectively. One hundred and nineteen pediatric patients with Risk Adjustment for Congenital Heart Surgery (RACHS) scores below 3 were randomly assigned using allocation software to two groups (CB and DN cardioplegia) according to the type of cardioplegia solution used. The change of urea, creatinine, estimated glomerular filtration rate (eGFR), and renal near-infrared spectroscopy (NIRS) values before and after cardioplegia were the primary outcome measures of this study. Results: Cardiopulmonary bypass (CPB) duration (p<0.001), ACC duration (p<0.001), and extubation time (p=0.032) were longer and the VIS-48th h (p=0.048) value was higher in the DN group. The pre-operative versus 48th h increase in urea were higher in the DN group (p=0.028). The increase in CPB duration was predictive for the increase in urea (p=0.009) and creatinine (p=0.004), and younger age was a predictor for the increase in urea (p=0.014) and decrease in eGFR (p=0.044).
No takes yet. Share an insight, caveat, or question.
Fatma Ukil Işıldak (2022) conducted an RCT in Congenital heart disease (n=119). Del Nido cardioplegia vs. Cold blood cardioplegia was evaluated on Pre-operative versus 48th hour increase in urea (p=0.028). Del Nido cardioplegia was as safe as cold blood cardioplegia regarding renal NIRS, creatinine, and eGFR changes during congenital heart surgery, despite a higher increase in urea at 48 hours (p=0.028).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: