Laboratory animal study reveals that prostaglandin F2alpha suppresses prostaglandin E-induced vascular permeability in rats, indicating inhibition of mast cell histamine release.
Key Points
To determine how prostaglandin F2alpha interacts with prostaglandins E1 and E2 and other vasoactive mediators to modulate dermal vascular permeability in rats.
Administered intradermal injections of PGE1 or PGE2 (0.1 µg) either alone or mixed with PGF1alpha (0.5–1 µg) or PGF2alpha (0.5 µg) into rats.
Evaluated cutaneous vascular permeability changes following injection of the histamine-releasing compound 48/80 (25 ng) or direct microvascular agents (histamine, 5-hydroxytryptamine, bradykinin) in the presence or absence of PGF2alpha.
Vascular permeability increases elicited by PGE1 or PGE2 (0.1 µg) were greatly reduced when combined with PGF2alpha, whereas PGF1alpha (0.5–1 µg) showed no inhibitory effect.
PGF2alpha (0.5 µg) inhibited cutaneous permeability increases triggered by compound 48/80 (25 ng), whereas PGF1alpha (0.5 µg) failed to inhibit this response.
Responses to direct microvascular stimulants (1 µg histamine, 0.1 µg 5-hydroxytryptamine, and 1 µg bradykinin) were not significantly altered by PGF2alpha (0.5 µg).