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The effect of Trypanosoma brucei infection on small blood vessels has been studied in regenerative ear-chambers in rabbits. Damage to the vessels was observed about 2 weeks after the animals had been inoculated with trypanosomes. Mononuclear phagocytic cells collected on the endothelium of the small venules, the blood flow was obstructed and the vessels disintegrated. Fibroblasts and collagen in the connective tissue degenerated. Few trypanosomes were present in the circulating blood but the tissue spaces contained many parasites. From time to time the trypanosomes in the tissue spaces were trapped and digested by phagocytes.
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L Goodwin (1971) studied this question.
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