Comparison Between the Effects of Glucose and Sodium Succinate on the in Vitro Release of Histamine from Guinea‐pig and Rat Lung Tissue1

Histamine release elicited under nitrogen anoxia by antigen from sensitized guinea‐pig lung tissue, and by compound 48/80 from non‐sensitized rat lung tissue, was enhanced by the presence of glucose but not by that of sodium succinate. In the presence of oxygen, sodium succinate as well as glucose enhanced antigen‐induced histamine release from guinea‐pig lung tissue. In contrast, histamine release from rat lung tissue induced by antigen, as well as by compound 48/80, was not enhanced by sodium succinate in the presence of oxygen, whereas glucose was effective in both reactions. Possible reasons for this species difference are discussed in the light of the supposition that the histamine‐releasing reactions investigated depend on adequate utilization of energy‐yielding substrates and of high‐energy compounds.