Answers are grounded in this paper and cite their sources.
LONP1 is a conserved mitochondrial AAA+ protease central to mitochondrial proteostasis. This review summarizes its structural features, protease-chaperone functions, and roles in metabolic regulation (heme/sulfur/steroid pathways) and disease. In cancer, LONP1 overexpression drives tumor progression via metabolic reprogramming, EMT induction, metastasis, and therapy resistance, establishing it as a pan-cancer therapeutic target. Inhibitors face delivery and selectivity challenges, prompting future strategies like mitochondrial-targeted delivery and allosteric modulators. Research directions include mechanistic studies and clinical translation for cancer and neurodegenerative disorders.
No takes yet. Share an insight, caveat, or question.
Xi et al. (2025) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: