Key result
Myocardial interstitial fibrosis was significantly more frequent in deaths due to left ventricular hypertrophy than in deaths due to ischemic heart disease and other causes (p < 0.001).
Why the study?
The study aimed to identify cardiac macroscopic and microscopic changes across causes of cardiovascular and sudden cardiac death, and evaluate challenges forensic practitioners encounter during autopsies.
Observational (n=1,045)
No
p-value: p=<0.001
Ischemic heart disease remains the leading cause of cardiovascular and sudden cardiac death in this autopsy cohort, though some causes of sudden death remain undetected despite detailed examination.
Reinforces IHD prevention focus; leaves open undetected causes and fibrosis mechanisms in LVH deaths.
This study aims to identify the macroscopic and microscopic changes that occur in the heart in different causes of cardiovascular death and sudden cardiac death in autopsy cases and evaluate the difficulties that a forensic practitioner may encounter during autopsies. All forensic autopsy cases in the Morgue Department of the Council of Forensic Medicine, Antalya Group Administration between January 1, 2015, and December 31, 2019, were examined, retrospectively. The cases were chosen according to inclusion and exclusion criteria, and their autopsy reports were examined in detail. It was determined that 1045 cases met the study criteria, 735 of which were also met the sudden cardiac death criteria. The top three common causes of death were ischemic heart disease (n = 719, 68.8%), left ventricular hypertrophy (n = 105, 10%), and aortic dissection (n = 58, 5.5%). The frequency of myocardial interstitial fibrosis was significantly higher in deaths due to left ventricular hypertrophy than in deaths due to ischemic heart disease and other causes (χ2(2) = 33.365, p < 0.001). Despite detailed autopsy and histopathological examinations, some heart diseases that cause sudden death may still not be detected.
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Deveci et al. (2023) conducted an observational in Cardiovascular death and sudden cardiac death (n=1,045). Left ventricular hypertrophy vs. Ischemic heart disease and other causes was evaluated on Myocardial interstitial fibrosis (p=<0.001). Myocardial interstitial fibrosis was significantly more frequent in deaths due to left ventricular hypertrophy than in deaths due to ischemic heart disease and other causes (p < 0.001).
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