Key result
Hypertension was associated with a significantly higher mean level of plateletcrit compared to non-hypertensive individuals (0.251% vs 0.235%, p=0.03), while other platelet volume indices were not significantly different.
Why the study?
Current literature on platelet indices in hypertensive disorders focused mainly on single indices rather than a set of platelet indices.
Does the pattern of platelet indices differ in patients with hypertensive disorders compared to non-hypertensive individuals?
Cross-Sectional (n=283)
No
Does the pattern of platelet indices differ in patients with hypertensive disorders compared to non-hypertensive individuals?
Hypertensive patients exhibit a distinct pattern of platelet indices characterized by elevated plateletcrit with normal mean platelet volume, platelet distribution width, and platelet large cell ratio.
Hypertension was associated with higher PCT but not other indices; hypothesis-generating for platelet activation and requires prospective validation.
Background. As a neglected piece of cell blood count, platelet indices are readily available in a primary care setting. Current literature aimed at the role of platelet indices in hypertensive disorders is focused mainly on a single platelet index. Objectives. To better clarify alterations in the pattern of platelet indices in hypertensive disorders, we investigated the relation between a set of platelet indices and hypertensive disorders defined by ambulatory blood pressure monitoring (ABPM). Material and methods. This cross-sectional study was conducted on 283 patients referred to the Hypertension Clinic of our hospital. ABPM was performed for all cases, and patients were accordingly classified as hypertensive (61.8%) and non-hypertensive (38.2%), as well as dipper (60%) and non-dipper (40%). Blood samples were collected for cell blood count, and ensuing platelet indices were compared between these groups.
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Najafi et al. (2023) conducted a cross-sectional in Hypertension (n=283). Hypertension vs. Non-hypertensive individuals was evaluated on Mean level of plateletcrit (PCT) (p=0.03). Hypertension was associated with a significantly higher mean level of plateletcrit compared to non-hypertensive individuals (0.251% vs 0.235%, p=0.03), while other platelet volume indices were not significantly different.
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