Key result
Vertical-cavity surface-emitting lasers (VCSELs) demonstrated rapid switching and reduced noise values to within a factor of 40% compared to non-coherent LED illumination for neural optical imaging.
VCSELs offer a promising illumination source for long-term, portable, continuous monitoring of brain hemodynamics in freely moving animals.
VCSELs may suit animal neural imaging; hypothesis-generating for portable brain hemodynamics monitoring, needs validation.
Neural optical imaging can evaluate cortical hemodynamic fluctuations which reflect neural activity and disease state. We evaluate the use of vertical-cavity surface-emitting lasers (VCSELs) as illumination source for simultaneous imaging of blood flow and tissue oxygenation dynamics ex vivo and in vivo and demonstrate optical imaging of blood flow changes and oxygenation changes in response to induced ischemia. Using VCSELs we show a rapid switching from a single-mode to a special multi-mode rapid current sweep operation and noise values reduced to within a factor of 40% compared to non-coherent LED illumination. These VCSELs are promising for long-term portable continuous monitoring of brain dynamics in freely moving animals.
No takes yet. Share an insight, caveat, or question.
Munro et al. (2011) studied Induced ischemia. Vertical-cavity surface-emitting lasers (VCSELs) vs. Non-coherent LED illumination was evaluated on Noise values and imaging of blood flow and oxygenation changes. Vertical-cavity surface-emitting lasers (VCSELs) demonstrated rapid switching and reduced noise values to within a factor of 40% compared to non-coherent LED illumination for neural optical imaging.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: