Key result
In untreated Black sub-Saharan African patients with mild-to-moderate hypertension, central hemodynamic indexes were largely normal, with only 18.3% of patients exceeding the healthy age-specific threshold for pulse wave velocity.
Cross-Sectional (n=116)
Yes
Black hypertensive patients in sub-Saharan Africa have measures of arterial stiffness similar to a healthy reference population, highlighting a significant potential for prevention of irreversible arterial damage through timely blood pressure treatment.
Background: Few studies assessed arterial stiffness in Black hypertensive patients born and living in sub-Saharan Africa, where cardiovascular disease reaches epidemic proportions. Methods:The Newer versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial is currently recruiting native African patients to compare the efficacy of various antihypertensive drugs given once daily as single-pill combinations.Two centres engaged in pulse wave analysis and measured carotidefemoral pulse wave velocity (PWV).Statistical methods included single and multiple linear regressions.Results: Of 172 patients screened, 116 entered the ancillary study on central haemodynamics (51.3% women; mean age 52.7 years; untreated blood pressure 147.6/87.1 mm Hg).The
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Ezeala‐Adikaibe et al. (2011) conducted a cross-sectional in Mild-to-moderate hypertension (n=116). Untreated mild-to-moderate hypertension vs. Healthy Black South African reference population was evaluated on Proportion of patients with arterial stiffness measurements above age-specific healthy thresholds (pulse wave velocity). In untreated Black sub-Saharan African patients with mild-to-moderate hypertension, central hemodynamic indexes were largely normal, with only 18.3% of patients exceeding the healthy age-specific threshold for pulse wave velocity.
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