Metabolism of Lithocholic Acid‐24–14c in Extrahepatic Biliary Atresia

Summary Lithocholic acid‐24‐14C was given to 2 infants with extrahepatic biliary atresia. After oral administration about half of the amount of isotope was found to be adsorbed. After par‐ 9. Makino, I., Sjovall, J., Norman, A. & Strandvik, enteral administration about half of the amount of isotope was excreted in the urine for 3 days. Lithocholic acid was shown to be transformed to a small extent to more polar compounds. These metabolites were not cholic, chenodeoxycholic, α‐ or,β‐muricholic, hyocholic, hyodeoxycholic or ursodeoxycholic acids. Most of the lithocholic acid was excreted as the sulphate esters of tauro‐ and glycolithocholic acid. No sulphate ester of lithocholic or free lithocholic acid was excreted.