Key result
Perioperative intravenous amino acid infusion was associated with a lower incidence of post-operative acute kidney injury compared to crystalloid fluids (10.5% vs 20.1%, p=0.022).
Why the study?
Post-operative acute kidney injury is a serious complication after major abdominal surgery, and it was unknown whether perioperative amino acid infusion reduces PO-AKI incidence in major urological minimally invasive surgery.
Does perioperative intravenous amino acid infusion reduce the incidence of post-operative acute kidney injury in patients undergoing major urological minimally invasive surgery?
Cohort (n=331)
Does perioperative intravenous amino acid infusion reduce the incidence of post-operative acute kidney injury in patients undergoing major urological minimally invasive surgery?
Perioperative intravenous amino acid infusion significantly reduced the incidence of post-operative acute kidney injury and hospital length of stay compared to crystalloid fluids in patients undergoing major urologic surgery.
May reduce PO-AKI after urologic surgery; leaves open confirmation by RCTs before practice change.
Post-operative acute kidney injury (PO-AKI) is a serious complication that may occur after major abdominal surgery. The administration of intravenous perioperative amino acids (AAs) has been proven to increase kidney function and has some beneficial effects to prevent PO-AKI. The aim of this study was to establish if the perioperative infusion of AAs may reduce the incidence of PO-AKI in patients undergoing major urological minimally invasive surgery. From a total of 331 patients, the first 169 received perioperative crystalloid fluids and the following 162 received perioperative AA infusions. PO-AKIs were much higher in the crystalloid group compared to the AA group (34 vs. 17, p = 0.022) due to a lower incidence of KDIGO I and II in the AA group (14 vs. 30 p = 0.016). The AA group patients who developed a PO-AKI presented more risk factors compared to those who did not (2 (2-4) vs. 1 (1-2), p = 0.031) with a cut-off of 3 risk factors in the ROC curve (p = 0.007, sensitivity 47%, specificity 83%). The hospital length of stay was higher in the crystalloid group (p < 0.05) with a consequent saving in hospital costs. Perioperative AA infusion may help reduce the incidence of PO-AKI after major urological minimally invasive surgery.
No takes yet. Share an insight, caveat, or question.
Brusasco et al. (2023) conducted a cohort in major urological minimally invasive surgery (n=331). perioperative intravenous amino acid infusion vs. perioperative crystalloid fluids was evaluated on incidence of post-operative acute kidney injury (PO-AKI) (p=0.022). Perioperative intravenous amino acid infusion was associated with a lower incidence of post-operative acute kidney injury compared to crystalloid fluids (10.5% vs 20.1%, p=0.022).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: