The electron microscopy contribution to platelet structural pathology investigation

This article discusses the role of electron microscopy in the diagnosis and study of morphological changes that cause platelet structural abnormalities in a variety of congenital diseases. Morphological abnormalities can be divided into the abnormalities of the platelet cytoskeleton, of alpha and dense granules, and membrane abnormalities. Our paper describes ultrastructural platelet defects in Wiskott–Aldrich syndrome, MYH9-associated syndromes, gray platelet syndrome, Hermansky–Pudlak syndrome, Paris–Trousseau syndrome, Chediak–Higashi syndrome.