Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study

Figures

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  FIGURE 1. Selection of participants. AL, acute leukemia; CAD, coronary artery disease; HAL, hyperleukocytic acute leukemia.

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  FIGURE 2. Comparison of cardiac function impairment indicators in acute leukemia, coronary artery disease, and control group patients. The T test was used to compare the myocardial enzyme and echocardiography indexes of the three group (A–D). (*represents p < 0.05, ** represents p < 0.01). BNP, B-type natriuretic peptide; CK, creatine kinase; CK-MB, creatine kinase myocardial band; DD, D-dimer; EDV, end-diastolic volume; ESV, end-systolic volume; EF, ejection fraction; hs-cTnI, highly sensitive troponin-I; HBDH, hydroxybutyrate dehydrogenase; IVS, interventricular septal; LVPW, left ventricular posterior wall; LDH, lactate dehydrogenase; LAID, left atrial internal diameter; LVID, left ventricular internal diameter; SV, stroke volume.

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  FIGURE 3. Subgroup analysis of non-hyperleukocytic and hyperleukocytic acute leukemia groups. The T test was used to compare BNP and myocardial enzyme and echocardiography indexes between the NHAL HAL groups (A–E). (** represents p < 0.01). AST, aspartate transaminase; ALT, alanine aminotransferase; BNP, B-type natriuretic peptide; BUN, blood urea nitrogen; Cr, creatinine; CK, creatine kinase; CK-MB, creatine kinase myocardial band; DD, D-dimer; EDV, end-diastolic volume; ESV, end-systolic volume; EF, ejection fraction; hs-cTnI, highly sensitive troponin-I; HBDH, hydroxybutyrate dehydrogenase; HAL, hyperleukocytic acute leukemia; IVS, interventricular septal; LVPW, left ventricular posterior wall; LDH, lactate dehydrogenase; LAID, left atrial internal diameter; LVID, left ventricular internal diameter; NHAL, non-hyperleukocytic acute leukemia; SV, stroke volume.

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  FIGURE 4. Survival curve of newly diagnosed acute leukemia patients. Log-rank test for univariate analysis of heart-related indicators in newly diagnosed acute leukemia patients through Kaplan-Meier curves. LDH, lactate dehydrogenase; EF, ejection fraction.

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  FIGURE 5. Forest plot for Cox regression analysis. Cox regression model for multivariate analysis. *p < 0.05, **p < 0.01. HRs and 95% CIs are estimated in Cox proportional hazards regression. CI, confidence interval; CK-MB, creatine kinase myocardial band; DD, D-dimer; EF, ejection fraction; HBDH, hydroxybutyrate dehydrogenase; HGB, hemoglobin; HRs, hazard ratios; LDH, lactate dehydrogenase; LVID, left ventricular internal diameter.

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  FIGURE 6. Receiver operating characteristic curves of LVID. The ROC curve using the clinical diagnosis of cardiac function as the dependent variable and myocardial enzymes, BNP, and echocardiography indicators as independent variables. LVID, left ventricular internal diameter; ROC, receiver operating characteristic; AUC, area under the curve.