Population
Cultured mouse fibroblast cell lines infected with Rickettsia tsutsugamushi strains, Rickettsia rickettsii…
Comparison
Recombinant rat IFN-gamma or purified mouse… vs Mock-treated control cultures
Design
Preclinical
Follow-up
up to 96 hours
Authors
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IFN-gamma susceptibility of R. tsutsugamushi is highly strain- and cell-dependent; hypothesis-generating for virulence mechanisms, should not yet change practice.
The susceptibility of Rickettsia tsutsugamushi to mouse interferons is highly dependent on both the rickettsial strain and the host cell line, which may relate to virulence differences in mice.
Barbara A. Hanson (1991) studied this question.
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